Pierre-Emerick Aubameyang prodded in on 11 minutes at a frenzied Signal Iduna Park to propel Dortmund up to third on 21 points Cheap Authentic Soccer Jerseys , three points behind Bayern, for whom this was a first defeat of the league season.
RB Leipzig is top, unbeaten and three points clear of the mighty Bayern, after a thrilling 3-2 win at Bayer Leverkusen on Friday signalled another
milestone in its fast rise to the top of German football.
Bayern captain Philipp Lahm admitted that neutrals would be delighted to see someone other than the Bavarians at the top. “It’s good for the Bundesliga, it’s
what the whole world wanted Cheap Soccer Jerseys ,” he added bitterly.
In Spain, Cristiano Ronaldo scored a hat-trick and Real Madrid handed rival Atletico a painful 3-0 loss in its last Spanish league derby before leaving
Vicente Calderon Stadium next season. The victory also snapped Madrid’s six-game
winless streak against the city rival, and gave the club a four-point lead over
Barcelona.
Barcelona was unable to overcome the absence of Lionel Messi and Luis Suarez in a 0-0 draw at Camp Nou, a result that ended its home scoring streak that
started in February 2015.
Madrid’s gap to Atletico increased to nine points, putting the rival’s title chances in jeopardy after only 12 matches.
Sevilla moved to third after a 3-2 win at Deportivo La Coruna.
SAN FRANCISCO Cheap Jerseys China Wholesale , Sept. 18 (Xinhua) -- By developing a way to better study a large protein essential for hearing and finding a truncated version of
it, researchers at Oregon State University (OSU) have taken a step toward gene
therapy for deaf patients.
While mutations in the protein, known as otoferlin, are linked to severe congenital hearing loss, a common type of deafness in which patients can hear
almost nothing Cheap Jerseys Online , the research suggests that otoferlin, which is in the cochlea of the inner ear, acts as a calcium-sensitive linker protein.
Published recently in the Proceedings of the National Academy of Sciences, or PNAS, the study also shows that a mutation in otoferlin weakens the binding
between the protein and a calcium synapse in the ear Cheap Jerseys Discount , and deficiencies in that interaction might be at the root of hearing loss related to otoferlin, which is difficult to study due to
the size of its molecule.
As they try to explore how otoferlin works differently than another neuronal calcium sensor in the brain, synaptotagmin, the researchers in OSU's College of
Science developed a single-molecule colocalization binding titration assay for
quantitatively probing otoferlin.
"Otoferlin seems only to have one purpose and that is to encode sound in the sensory hair cells in the inner ear," corresponding author Colin
Johnson Cheap Jerseys Wholesale , associate professor of biochemistry and biophysics, explained in a news release from OSU Monday. "And small mutations in otoferlin
render people profoundly deaf."
The work by Johnson and his collaborators provides a molecular-level explanation for the observation that otoferlin and synaptotagmin don't have the
same functional role. Performed using recombinant protein from cell lysate
isolated in vitro, it also validates a methodology for characterizing large,
multivalent membrane proteins in general.
"The otoferlin gene is really big, and it makes a huge protein Cheap Jerseys From China ," Johnson said. "The traditional method for making a recombinant protein is using E. coli, but they loathe big proteins." While there
is a size limit in terms of what can be packaged into the gene delivery vehicle,
the researchers tried to shorten the gene, to find a truncated form that can be
used for gene therapy.
"That's the holy grail, trying to find a miniature version of otoferlin that can be packaged into the delivery vehicle and then hopefully the patient can
start hearing Cheap Jerseys China ," he noted. As a result, the team identified a truncated form of otoferlin that can function in the encoding of sound.
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