Caffeic acid phenethyl ester (CAS 104594-70-9)

CAPE (Caffeic acid phenethyl ester powder) is a constituent of the propolis of honeybee hives and has been shown
to contain inhibitory effects on induced papilloma promotion in mice.
Studies have shown that CAPE acts as an anti-proliferative agent in
over-productive cell growth. It is also shown that CAPE can cause DNA
fragmentation and apoptosis which can have toxic results towards cloned
rat embryo fibroblast (CREF) cells. In addition, CREF cells depleted of
cellular glutathione (GSH) seemed to be more sensitive to CAPE-induced
cell death.

CAPE has been reported to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. CAPE also inhibits HIV-1 integrase.
The anti-inflammatory characteristics have been thought to be due to
suppression of the lipoxygenase pathway of arachidonic acid metabolism
by CAPE. Studies have also demonstrated CAPE to be a specific and potent
inhibitor of activation of nuclear transcription factor NF kappa B,
which is a protein complex that controls the transcription of DNA. CAPE
(Caffeic Acid Phenethylester) is an inhibitor of ODC and Tyrosine
Kinase.

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