TOP sale Carvedilol/72956-09-3/high quality Carvedilol

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TOP sale Carvedilol/72956-09-3/high quality Carvedilol

Chemical Name: 1-(9H-Carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol
Cas No.: 72956-09-3
Molecular Formula: C24H26N2O4
Molecular Weight: 406.48
Melting point: 113-117ºC
Density:1.25 g/cm3
Boiling Point: 655.2 °C at 760 mmHg
Flash Point: 350.1 °C
Appearance: white or almost white crystalline powder
Assay:98%min
Usage: Carvedilol powder is a non-selective beta blocker/alpha-1 blocker indicated in the treatment of mild to moderate congestive heart failure (CHF).
Carvedilol is a AR (a1 and ß-adrenergic receptor) antagonist with antioxidant properties. Studies show that the receptors a1D-AR and
a1B-AR have a greater affinity for Carvedilol in comparison to the
receptor ß1-AR subtype. Carvedilol has been observed to block the
oscillatory intracellular calcium changes induced by a1D-AR and a1B-AR,
and shown to have a higher oxidative effect than Atenolol (sc-204895).
The S(-) enantiomer of Carvedilol acts as a ß-blocker, and the R(+) and S
(-) enantionmers both block the a1. Carvedilol is an inhibitor of
a1B-AR, ß1-AR, ß2-AR and a1D-AR.

Posted 18 Oct 2019

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