DRUGS

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^manie^

Age: 124
Total Posts: 359
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has anyone done them?
or knows anyone who do..o have done?

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Posted 18 Apr 2005

Ashii says
o nashae diye band botlaae
Posted 30 Apr 2005

2HOT4U says
know plenty of people who do them.
Posted 30 Apr 2005

^manie^ says
HOW TO MAKE COCAINE
this a manie's special so be proud of urelves.

The basic formula for cocaine starts by purchasing or making tropinine,


converting the tropinone into 2-carbomethoxytropinone (also known as


methyl-tropan-3-one-2-carboxylate), reducing this to ecgonine,


and changing that to cocaine.


Succindialdehyde. This can be purchased, too. 23.2 g of succinaldoxime


powder in 410 ml of 1 N sulfuric acid and add dropwise with stirring at


0* a solution of 27.6 g of sodium nitrite in 250 ml of water over


3 hours. After the addition, stir and let the mixture rise to room temp


for about 2 hours, taking care not to let outside air into the reaction.


Stir in 5 g of Ba carbonate and filter. Extract the filtrate with ether


and dry, evaporate in vacuo to get the succindialdehyde. This was t


aken from JOC, 22, 1390 (1957). To make succinaldoxime, see JOC, 21,


644 (1956).


Complete Synthesis of Succindialdehyde. JACS, 68, 1608 (1946). In a 2 liter


3 necked flask equipped with a stirrer, reflux condenser, and an addition


funnel, is mixed 1 liter of ethanol, 67 g of freshly distilled pyrrole, and


141 g of hydroxylamine hydrochloride. Heat to reflux until dissolved, add


106 g of anhydrous sodium carbonate in small portions as fast as reaction


will allow. Reflux for 24 hours and filter the mixture. Evaporate the


filtrate to dryness under vacuo. Take up the residue in the minimum amount


of boiling water, decolorize with carbon, filter and allow to recrystallize


in refrigerator. Filter to get product and concentrate to get additional


crop. Yield of succinaldoxime powder is a little over 40 g, mp is 171-172*.


5.8 g of the above powder is placed in a beaker of 250 ml capacity and


54 ml of 10% sulfuric acid is added. Cool to 0* and add in small portions


of 7 g of sodium nitrite (if you add the nitrite too fast, nitrogen dioxide


fumes will evolve). After the dioxime is completely dissolved, allow the


solution to warm to 20* and effervescence to go to completion. Neutralize


the yellow solution to litmus by adding small portions of barium carbonate.


Filter off the barium sulfate that precipitates. The filtrate is 90% pure


succindialdehyde and is not purified further for the reaction to create


tropinone. Do this procedure 3 more times to get the proper amount for the


next step, or multiply the amounts given by four and proceed as described


above.


Take the total amount of succinaldehyde (obtained from 4 of the above


syntheses combined) and without further treatment or purification (this had


better be 15.5 g of succindialdehyde) put into an Erlenmeyer flask of


4-5 liters capacity. Add 21.6 g of methylamine hydrochloride, 46.7 g of


acetonedicarboxylic acid, and enough water to make a total volume of 2


liters. Adjust the pH to 8-10 by slowly adding a saturated solution of


disodium phosphate. The condensate of this reaction (allow to set for


about 6 days) is extracted with ether, the ethereal solution is dried


over sodium sulphate and distilled, the product coming over at 113* at


25 mm of pressure is collected. Upon cooling, 14 g of tropinone


crystallizes in the pure state.


2-Carbomethoxytropinone. A mixture of 1.35 g of sodium methoxide


(this is sodium in a minimum amount of methanol), 3.5 g of tropinone,


4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min.


Cool to 0* and add 15 ml of water that contains 2.5 g of ammonium chloride.


Extract the solution after shaking with with four 50 ml portions of


chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil


residue in 100 ml of ether, wash twice with a mixture of 6 ml of


saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate


in vacuo to recover the unreacted tropinone. Take up the oil in a solution


of aqueous ammonium chloride and extract with chloroform, dry, and evaporate


in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and


scratch inside of flask with glass rod to precipitate


2-carbomethoxytropinone. Recrystallize 16 g of this product in 30 ml of hot


methyl acetate and add 4 ml of cold water and 4 ml of acetone. Put in


freezer for 2 1/2 to 3 hours. Filter and wash the precipitate with cold


methyl acetate to get pure product.


Methylecgonine. 0.4 mole of tropinone is suspended in 80 ml of ethanol


in a Parr hydrogenation flask (or something that can take 100 psi and not


react with the reaction, like stainless steel or glass). 10 g of Raney


Nickle is added with good agitation (stirring or shaking) followed by


2-3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen


atmosphere (after flushing vessel with hydrogen) and heat to 40-50*.


After no more uptake of hydrogen (pressure gauge will hold steady after


dropping to its lowest point) bleed off pressure and filter the nickle off,


rinse out bottle with chloroform and use this rinse to rinse off the nickle


while still on the filter paper. Make the filtrate basic with KOH after


cooling to 10*. Extract with chloroform dry, and evaporate the chloroform


in vacuo to get an oil. Mix the oil plus any precipitate with an equal


volume of dry ether and filter. Add more dry ether to the filtrate until


no more precipitate forms, filter and add to the rest of the precipetate.


Recrystallize from isopropanol to get pure methylecgonine. Test for activity.


If active, skip down to the step for cocaine. If not active, proceed as


follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo,


dissolve the brown liquid in methanol, and neutralize with 10% HCl acid in


dry ether. Evaporate the ether until the two layers disappear, and allow to


stand for 2 hours at 0* to precipitate the title product. There are many


ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design


a Raney Nickle reduction because it is cheap and not as suspicious as LAH


and it is much easier than zinc or sodium amalgams.


Cocaine. 4.15 g of methylecgonine and 5.7 g of benzoic anhydride in 150 ml


of dry benzene are gently refluxed for 4 hours taking precaution against


H20 (the 2 should be on a lower level) in the air (drying tube). Cool in an


ice bath, acidify carefully with hydrochloric acid, dry, and evaporate in a


vacuum to get a red oil which is treated with a little portion of isopropanol


to precipitate cocaine.


As you can see, this is quite a chore. The coca leaves give ecgonine, which


as you can see, is only a jump away from cocaine. If you can get egconine,


then dissolve 8 1/2 g of it in 100 ml of ethanol and pass (bubble) dry HC1


gas through this solution for 30 min. Let cool to room temp and let stand


for another 1 1/2 hours. Gently reflux for 30 min and evaporate in vacuo.


Basify the residue oil with NaOH and filter to get 8.4 g of methylecgonine,


which is converted to cocaine as in the cocain step above.


Below is given a somewhat easier method of producing tropinone by the


general methods of Willstatter, who was instrumental in the first synthetic


production of cocaine and several other alkaloids. After reviewing this



method, I found it to be simpler than the above in many respects.


Tropinone. 10 g of pyrrolidinediethyl diacetate are heated with 10 g of


cymene and 2 g of sodium powder, the reaction taking place at about 160*.


During the reaction (which is complete in about 10 min) the temp should not


exceed 172*. The resulting reaction product in dissolved in water, then


saturated with potassium carbonate, and the oil, which separates, is boiled


with dilute sulfuric acid. 2.9 g of tropinone picrate forms and is filtered.


Here are two more formulas devised by Willstatter that produce tropinone


from tropine. Take note of the yield differences.


Tropinone. To a solution of 25 g tropine, dissolved in 10 times its weight


of 20% sulfuric acid are added 25 g of a 4% solution of potassiumpermanganate


in 2 or 3 g portions over 45 min while keeping the temp at 10-12*. The


addition of permanganate will cause heat (keep the temp 10-12*) and


precipitation of manganese dioxide. The reaction mixture is complete in


1 hour. A large excess of NaOH is added and the reaction is steam distilled


until 1 liter of distillate has been collected. The tropinone is


isolated as the dibenzal compound by mixing the distillate with 40 g of


benzaldehyde in 500 cc of alcohol and 40 of 10% sodium hydroxide solution.


Let stand several days to get dibenzaltropinone as yellow needles.


Yield: 15.5 g, 28%. Recrystallize from ethanol to purify.


Tropinone. A solution of 12 g of chromic acid in the same amount of


water (12 g) and 60 g of glacial acetic acid is added dropwise with stirring


over a period of 4 hours to a solution of 25 g of tropine in 500 cc of


glacial acetic acid that has been warmed to 60-70* and is maintained at this


temp during the addition. Heat the mixture for a short time on a steam bath


until all the chromic acid has disappeared, cool and make strongly alkaline


with NaOH. Extract with six 500 cc portions of ether and evaporate the ether


in vacuo to get an oil that crystallizes readily. Purify by convering to the


picrate or fractionally distill, collecting the fraction at 224-225* at


714 mm vacuo.


The tropinones can be used in the above formula (or in a formula that you


have found elsewhere) to be converted to cocaine. Remember to recrystallize


the 2-carbomethoxytropinone before converting to methylecgonine.
Posted 30 Apr 2005

Bazigaar says
mani stop searching on google and copy pasting stuff over here

i am old guy..mushrooms r good enough for me
Posted 01 May 2005

^manie^ says
i assur eu
this isnt from google mate
i kind agot friend with this girl from singapore
whose doing a phd in chemistry
and we r gonna make some hme made ectasy
bwahahahhaa
Posted 03 May 2005

valandrian says
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